Dual functional construct containing kartogenin releasing microtissues and curcumin for cartilage regeneration

Co-Culture of Mesenchymal Stem Cells with Mature Chondrocytes: Producing Cartilage Construct for Application in Cartilage Regeneration

Background: Cell-based treatment approach using differentiated mesenchymal stem cells (MSCs) and mature chondrocytes has been considered as an advanced treatment for cartilage repair. We investigated the differentiated level of these two cell types that is crucial for their repair capacity for cartilage defect at a co-culture micro mass system. Methods: Passaged-2 MSCs isolated from the mouse b...

co-culture of mesenchymal stem cells with mature chondrocytes: producing cartilage construct for application in cartilage regeneration

background: cell-based treatment approach using differentiated mesenchymal stem cells (mscs) and mature chondrocytes has been considered as an advanced treatment for cartilage repair. we investigated the differentiated level of these two cell types that is crucial for their repair capacity for cartilage defect at a co-culture micro mass system.   methods: passaged-2 mscs isolated from the mouse...

Regulation of lubricin for functional cartilage tissue regeneration: a review

Background Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and...

Dual growth factor releasing multi-functional nanofibers for wound healing.

The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote ang...

Intra-articular Delivery of Kartogenin Conjugated Chitosan Nano/microparticles for Cartilage Repair